Sino Biological, Inc. (Shenzhen Stock Exchange: 301047.SZ), a global leader in recombinant technology, has launched the XPressMAX™ Cell-Free Protein Synthesis Kit (Cat#: CFKIT02), a new tool designed to accelerate AI-powered high-throughput screening for antibody drug discovery. The kit leverages advanced cell-free protein synthesis technology to produce target proteins and antibodies in vitro within 3 hours, eliminating the constraints of traditional cell-based expression systems.
Based on an E. coli lysate fully supplemented with essential transcription and translation components, XPressMAX™ enables direct protein synthesis from plasmid or PCR templates. It is specifically designed for antibody drug discovery, supporting rapid expression and validation of VHH, scFv, Fab, and Miniprotein. According to the company, the technology achieves a success rate greater than 99% and supports complex disulfide bonding for native folding and bioactivity without additional enhancers.
The launch comes as AI is revolutionizing antibody screening, but demands expression systems that can match its speed and throughput. Sino Biological has established a high-throughput cell-free expression platform that validates over 2,000 scFv/VHH molecules in 3-4 weeks using XPressMAX™, aligning with AI's rapid iteration capabilities. This integration aims to compress antibody discovery timelines without compromising quality.
“Our XPressMAX™ is a significant advancement in research tools and reagents for next-generation therapeutic discovery,” said Dr. Rob Burgess, Chief Business Officer at Sino Biological US, Inc. “By combining rapid, reliable protein expression with intelligent screening, we are helping our partners compress antibody discovery timelines without compromising quality.” Dr. Jie Zhang, Sino Biological’s General Manager, added, “AI is revolutionizing antibody screening, but it demands expression systems that can match its speed and throughput. XPressMAX™ achieves rapid, high-success expression of challenging proteins in as little as 3 hours.”
Researchers can visit Sino Biological's website to explore more about XPressMAX™ or request a free sample. Additional details on the cell-free protein synthesis system are available at the product page, and the company's cell-free solutions can be found here.
Sino Biological is an international reagent supplier and CRO service provider specializing in recombinant protein production and antibody development. With the US-based Center for Bioprocessing (C4B) in Houston and SignalChem Biotech in Canada, the company delivers tailored, localized solutions to researchers in over 90 countries.
